Eyes injected with the ataxin-7 ASO retained the ability to see, unlike the control eyes.
The scientists then measured how retinal neurons responded to light stimulation to determine whether the vision improved or deteriorated.
Better vision was correlated with lower levels of ataxin-7 mRNA and there was less accumulation of the misfolded protein.
The treatment suggests it might stop or even reverse blindness.
ASOs and related therapies suggest medical research may create powerful new treatments for many neurodegenerative diseases within the next decade.
I’ve seen a lot of articles in the past about treatments for blindness. This is one of the many that seem really promising and exciting.
An ASO is a short stretch of DNA that is synthesised to create a sequence that perfectly matches the target RNA